4-{3-[(Piperidin-1-yl)methyl]phenoxy}butanenitrile → 4-(3-Piperidinomethylphenoxy)butaneamine

Participants

Reaction Steps

In a similar manner to that of Example 16 (ii) reaction of 4-[3-(piperidinomethyl)phenoxy]butyronitrile (2.58 g) and lithium aluminium hydride (0.46 g) gave 4-[3-(piperidinomethyl)phenoxy]butylamine (2.55 g) as an oil. This oil and 2-chlorobenzthiazole (1.81 g) were fused at 130° C. for 4 hours. The cooled residue was subjected to column chromatography on silica using dichloromethane:methanol:ammonium hydroxide (90:5:05) as eluant to give the title compound (1.6 g), m.p. 92°-93° C. (recrystallised from toluene).

Provenance & Evidence