Chloroform → HCID 23035469, compound

HRID 2118982Notes

Reaction equation

HRID 2118982 reaction equation
[N:1]1([CH2:6][C:7]2[CH:8]=[C:9]([CH:15]=[CH:16][CH:17]=2)[O:10][CH2:11][CH2:12][CH2:13][NH2:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[C:19]1[S:20][C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[N:23]=1.C(Cl)(Cl)Cl>C(Cl)(Cl)Cl.CO>[N:1]1([CH2:6][C:7]2[CH:8]=[C:9]([CH:15]=[CH:16][CH:17]=2)[O:10][CH2:11][CH2:12][CH2:13][NH:14][C:19]2[S:20][C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=3[N:23]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 119872-ChlorobenzothiazoleHCID 127974543-{3-[(Pyrrolidin-1-yl)methyl]phenoxy}propan-1-amine

Product 1

HCID 23035469HCID 23035469, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

3-[3-(Pyrrolidinomethyl)phenoxy]propylamine (2.0 g) and 2-chlorobenzthiazole (1.45 g) were fused at 130° C. for 21/2 hours. The cooled reaction mixture was subjected to column chromatography on silica using chloroform and then chloroform:methanol (10:1) as eluants to give the title compound as a yellow oil. This was treated with maleic acid in ethanol to give 2-[3-[3-(pyrrolidinomethyl)phenoxy]propylamino]benzthiazole dimaleate (0.35 g), m.p. 91°-92° C. (recrystallised from isopropanol/ether).

Workup

  1. customwere fused at 130° C. for 21
  2. custom2 hours
  3. customThe cooled reaction mixture

Sources & evidence

ORD record
ord-6ca3fb0d95b644c28f644d8490957c12
Source dataset
uspto-grants-1987_07
Patent number
US04681883

Reaction notes

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