Hexane → HCID 178468081, compound

Participants

Reaction Steps

A mixture of 35 grams (0.1 mole) of N-phenyl-N-(2-dimethylaminoethyl)-5-methyl-3-phenyl-4-isoxazole carboxamide and 3.8 grams of 10% palladium on carbon in 200 milliliters of dimethylformamide is hydrogenated at 50 psi and 50°-60° C. overnight. The mixture is cooled, filtered, and the filtrate evaporated in vacuo. The residue obtained is then treated with hexane and the resulting crystals triturated with ether to give 2-(aminophenylmethylene)-N-(2-dimethylaminoethyl)-N-phenyl-3-oxobutanamide; M.P. 81°-83° C.

Provenance & Evidence