HCID 20192358, compound → HCID 178457328, compound

Participants

Reaction Steps

A mixture of 15.3 grams (0.048 mole) of N-(m-fluorophenyl)-N-(2-dimethylaminoethyl)-3-ethyl-5-methyl-4-isoxazole carboxamide and 1.5 grams of 10% palladium on carbon in 120 ml. of ethanol is hydrogenated at 50 psi at room temperature overnight. The catalyst is then removed by filtration and the solvent evaporated in vacuo. The residue is crystallized from ether; petroleum ether (1:1) to give 2-acetyl-3-amino-N-(2-dimethylaminoethyl)-N-(m-fluorophenyl)-2-pentenamide (m.p. 96°-97° C.).

Provenance & Evidence