HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2119004Generated: November 2, 2026
Benzene, 1-(chloromethyl)-2-fluoro- → HCID 13689386, compound
https://huagongshe.com/reaction/2119004
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzene, 1-(chloromethyl)-2-fluoro- | HCID 9580 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 11-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine | HCID 13689358 | — |
| Product | HCID 13689386 | HCID 13689386 | — |
Reaction Steps
To a solution of 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (5.0 g; 0.010 mole in 75 ml DMF) and 10 g milled K2CO3 was added 2-fluorobenzyl chloride (3.18 g; 0.022 mole in 15 ml DMF). This was stirred at 85° C. for 1.5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04681879 |
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| Source dataset | uspto-grants-1987_07 |
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| ORD ID | ord-817fac211316455a9552afe043265cee |
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| Source note | uspto-grants-1987_07 |
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