Acetate → HCID 178476464, compound

Participants

Reaction Steps

N-(o-Ethoxycarbonylphenyl)-trans-4-guanidinomethylcyclohexanecarboxamide hydrochloride (370 mg, 0.001 mole) prepared in Example 1 is dissolved in a mixture of water-methanol (1:1) and thereto is added ion exchange resin (Amberlite®IRA-400, manufactured by Rohm & Haas, which is previously converted into acetate type) (15 ml), and the mixture is stirred at room temperature overnight. After filtering off the resin, the filtrate is concentrated and recrystallized from water to give the title compound (300 mg) as white crystals. m.p. 212°-214° C.

Provenance & Evidence