HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 54156280, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Chloropurine riboside | HCID 93003 | — |
| Reactant | 3,4-Dihydro-2H-1-benzopyran-4-amine--hydrogen chloride (1/1) | HCID 44630710 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 54156280 | HCID 54156280 | 66% |
Reaction Steps
A mixture of 0.97 g of 6-chloropurine riboside, 0.7 g of 4-chromanylamine hydrochloride, and 0.94 g of triethylamine is refluxed in 30 ml ethanol under nitrogen for 20 hrs. The solvent is evaporated to dryness. The residual solid is treated with cold water. Clear aqueous solution is decanted off and the residue is dissolved in ethanol. Volatiles are evaporated under vacuuo. This is repeated once more affording 0.9 g (66%) of N6 -[4-chromanylamino]adenosine having a melting point of 125°-130° (foam).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04683223 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-ddeea7a8f4c84bb38818f3c7a94a8e36 |
| Source note | uspto-grants-1987_07 |