Water → HCID 13577656, compound

Participants

Reaction Steps

A solution of 3.12 g (0.1 mole) of 2-amino-3-benzoyl-5-chlorobenzeneacetic acid, sodium salt in 250 ml of dry tetramethylfuran was treated with 44 g of ethyl iodide (0.3 mole) under nitrogen and stirred for 2 hours. The resulting solution was then added to 1 liter of water and extracted several times with ethyl ether. The combined ether layers were washed with water, dried over sodium sulfate, filtered and stripped to yield a solid yellow residue. This material was recrystallized from absolute ethyl alcohol to give 1.5 g, yellow needles, m.p. 80°-82° C.

Provenance & Evidence