Triethylamine → Cyclopropylmethyl 3-oxobutanoate
反応式
[CH:1]1([CH2:4][OH:5])[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH2:13]=[C:14]1[O:18][C:16](=[O:17])[CH2:15]1>Cl>[C:16]([O:5][CH2:4][CH:1]1[CH2:3][CH2:2]1)(=[O:17])[CH2:15][C:14]([CH3:13])=[O:18]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To 13.2 g (179 millimole) of cyclopropyl-carbinol dissolved in 18.1 g (179 millimole) of triethylamine was slowly added 14 ml (179 millimole) of diketene at 0° C. The mixture was stirred at 0° C. for 10 minutes and at room temperature for 30 minutes, diluted with 3% aqueous HCl solution and extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated under the reduced pressure to obtain 24 g of cyclopropylmethyl acetoacetate as an oil.
後処理
- customat 0° C
- extractionextracted with chloroform
- dry with materialThe organic layer was dried over anhydrous magnesium sulfate
- customthe solvent was evaporated under the reduced pressure
出典と根拠
- ORDレコード
- ord-36dabe6f0a8c4c2f95e69cc12b0cdb9b
- 出典データセット
- uspto-grants-1987_07
- 特許番号
- US04683234
反応ノート
読み込み中…