Ethyl chloroformate → HCID 13689592, compound

Participants

Reaction Steps

270 mg (0.82 millimole) of 2,6-Dimethyl-5-cyclopropylmethoxycarbonyl-4-(2-nitrophenyl)-dihydropyrimidine in 4 ml of anhydrous tetrahydrofuran was added to 47 mg (0.98 millimole) of sodium hydride as 50% suspension in oil and stirred at room temperature for 5 minutes. Ethyl chloroformate (120 μl), 1.32 millimole) was added and stirred at room temperature for 30 minutes. The reaction solution was diluted with saturated aqueous NaCl solution and extracted with chloroform. The extract was dried over anhydrous magnesium sulfate and evaporated under reduced pressure to remove the solvent. The residue was purified on silica gel by thin layer chromatography (developer:chloroform/acetone 10:1, eluant : chloroform/methanol 4:1) to obtain 196 mg (yield 60%) of title compound.

Provenance & Evidence