Pivaloyl chloride → 2,7-Dipivaloyloxyfluorenone

HRID 2119173Notes

Reaction equation

HRID 2119173 reaction equation
[OH:1][C:2]1[C:3](=[O:16])[C:4]2[C:12](=[CH:13][CH:14]=1)[C:11]1[C:6](=[CH:7][C:8]([OH:15])=[CH:9][CH:10]=1)[CH:5]=2.[C:17](Cl)(=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19]>N1C=CC=CC=1>[C:17]([O:1][C:2]1[C:3](=[O:16])[C:4]2[C:12](=[CH:13][CH:14]=1)[C:11]1[C:6](=[CH:7][C:8]([O:15][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:9][CH:10]=1)[CH:5]=2)(=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19]

Participants

4

Reactant 2

HCID 62493Pivaloyl chlorideHCID 1363657952,7-Dihydroxylfluorenone

Product 1

HCID 703773292,7-Dipivaloyloxyfluorenone

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2.1 g (0.01 mole) of 2,7-dihydroxyfluorenone and 2.5 g (0.025 mole) of pivaloyl chloride were warmed to 50° C. in 6 mls of pyridine in a drying tube attached for 2 hrs. The solvent was removed via rotary evaporator and H2O was added. The crystals were filtered and air dried. Recrystallized from ethanol; 3 g (79%); M.P.~174°-175° C.

Workup

  1. customThe solvent was removed via rotary evaporator and H2O
  2. additionwas added
  3. filtrationThe crystals were filtered
  4. customair dried
  5. customRecrystallized from ethanol

Sources & evidence

ORD record
ord-aa7e355a73354ba68d8cf64be12a5b52
Source dataset
uspto-grants-1987_07
Patent number
US04683241

Reaction notes

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