Dimethyl Sulfoxide → HCID 14010393, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.8 ml of oxalyl chloride in 43 ml of methylene chloride were added dropwise a solution of 3.0 ml of DMSO in 9 ml of methylene chloride at -60° C., and then a solution of 6.14 g of 3-(2-methylhydroxypropyl-4-pivaloyloxybenzophenone in 17 ml of methylene chloride. The mixture was stirred at about -50°-60° C. for 15 min, then treated with 12.1 ml of triethylamine. The reaction mixture was stirred at -50° C. for 5 min, warmed to 25° C., and then treated with 85 ml of water. The organic layer was washed with dilute hydrochloric acid and then with brine, dried (MgSO4) and concentrated to give 5.0 g of product as an oil.

Provenance & Evidence