Triethylamine → HCID 13430187, compound

Participants

Reaction Steps

To a solution of 1.07 g (3 mmol) (2R) methyl 2-((3S,4S)-4-acetoxy-3-t-butyloxycarbonylaminoazetidine-2-on-1-yl)-3-methylbut-3-enoate in 30 ml of methylene chloride, at room temperature 0.3 ml of triethylamine is added and the reaction mixture stirred for 6 hours at room temperature. The reaction mixture is first washed with 15 ml of 1N hydrogen chloride in water and then with 15 ml of saturated sodium chloride solution. The organic layer is dried over sodium sulfate and the solvent removed in vacuo, leaving 1.07 g (100%) of a noncrystalline solid (title compound). IR spectrum in methylene chloride: 3420, 3000, 1790, 1760, 1725, 1505, 1385, 1365, 1215 and 1150 cm-1.

Provenance & Evidence