反应详情

A mixture of ethyl 8-[benzyl(methyl)amino]4-hydroxy-6-(4-morpholinylmethyl)-3-quinolinecarboxylate (500 mg, 1.15 mmol), 10% palladium charcoal (0.25 g) in ethanol (100 mL) is hydrogenated (50 psi initial hydrogen pressure) until HPLC shows that all the starting material has been reduced (2.5 h). The solution is filtered, the solvent removed, and the residual oil is applied in chloroform to a silica gel column which is eluted with 5-10% methanol/chloroform. After elution of a small amount of ethyl 4-hydroxy-8-(methylamino)-6-methyl-3-quinolinecarboxylate, the title compound (280 mg) is obtained.

1. custom(2.5 h)
2. filtrationThe solution is filtered
3. customthe solvent removed
4. washis eluted with 5-10% methanol/chloroform
5. washAfter elution of a small amount of ethyl 4-hydroxy-8-(methylamino)-6-methyl-3-quinolinecarboxylate