Benzyl Alcohol → HCID 20616878, compound

Participants

Reaction Steps

To a solution of 2-{3-[(t-butoxy)carbonylamino]cyclohexyl}acetic acid (3.43 g, 13.35 mmol), Et3N (3.75 mL, 26.96 mmol) in toluene (86 mL) under N2 was added DPPA (5.8 mL, 26.96 mmol) and benzyl alcohol (4.28 mL, 41.38 mmol). The solution was heated to reflux overnight. The reaction was cooled to room temperature, diluted with EtOAc, washed (1.0N NaOH then brine), dried (MgSO4), filtered, and concentrated. Column chromatography (silica gel, hexanes/EtOAc gradient) gave the title compound (3.05 g, 63%). Mass Spectrum (ES+) (m/z) 263.1 [M−BOC].

Provenance & Evidence