4-Fluoroaniline → HCID 23440877, compound

HRID 2119486Notes

Reaction equation

HRID 2119486 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[F:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][CH:14]=1>>[F:12][C:13]1[CH:19]=[CH:18][C:16]([NH:17][C:9](=[O:11])[CH2:8][C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([OH:1])[CH:3]=2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 97314-FluoroanilineHCID 121223'-Hydroxyphenylacetic acid

Product 1

HCID 23440877HCID 23440877, compoundYield 89%

Procedure

The title compound was prepared as described in Example 44.A, using 3-hydroxyphenyl acetic acid (80 g, 0.52 mol) and 4-fluoroaniline (49.3 ml, 0.52 mol) to provide the title compound (113 g, 89% yield): ES−MS (m/z) 246 [M+H]+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-1dafeca238ce41e299f46896381f8b8d
Source dataset
uspto-grants-2004_02
Patent number
US06686351B2

Reaction notes

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