Methyl iodide → HCID 178478955, compound

HRID 2119580Notes

Reaction equation

HRID 2119580 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([F:9])[C:3]=1[NH:10][C:11]([NH:13][C:14]1[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:21])=S.CI>>[ClH:20].[Cl:21][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]([Cl:20])[C:14]=1[NH:13][C:11]1[NH:10][C:3]2[C:4]([F:9])=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[N:1]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 22288821N-(2-Amino-4,6-difluorophenyl)-N′-(2,6-dichlorophenyl)thiourea

Product 1

HCID 178478955HCID 178478955, compound

Procedure

2-(2,6-Dichlorophenylamino)-4,5-difluorobenzimidazole hydrochloride was obtained analogously to the procedure described in example 9b from 2 g of 1-(2-amino-4,6-difluorophenyl)-3-(2,6-dichlorophenyl)thiourea and 6.4 g of methyl iodide. Crystalline solid, m.p.: 232-234° C.

Sources & evidence

ORD record
ord-38e2f4a89bee4e8f8ef6b4c9c4dc1900
Source dataset
uspto-grants-2004_02
Patent number
US06686384B2

Reaction notes

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