2-Bromo-2'-chloroacetophenone → {3-[5-(2-Chloro-benzoyl)-thiazol-2-ylamino]-propyl}-carbamic Acid tert-butyl Ester

HRID 2119588Notes

Reaction equation

HRID 2119588 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([N:14]=[CH:15]N(C)C)=[S:13])([CH3:4])([CH3:3])[CH3:2].[Cl:20][C:21]1[CH:30]=[CH:29][CH:28]=[CH:27][C:22]=1[C:23](=[O:26])[CH2:24]Br>>[C:1]([O:5][C:6](=[O:19])[NH:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]1[S:13][C:24]([C:23](=[O:26])[C:22]2[CH:27]=[CH:28][CH:29]=[CH:30][C:21]=2[Cl:20])=[CH:15][N:14]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 27357852-Bromo-2'-chloroacetophenoneHCID 72965844[3-(3-Dimethylaminomethylene-thioureido)-propyl]-carbamic Acid tert-butyl Ester

Product 1

HCID 20616902{3-[5-(2-Chloro-benzoyl)-thiazol-2-ylamino]-propyl}-carbamic Acid tert-butyl Ester

Procedure

The title compound was synthesised from [3-(3-Dimethylaminomethylene-thioureido)-propyl]-carbamic acid tert-butyl ester and 2-chloro phenacylbromide (commercially available) according to the procedure described for Example 25. MS (m/e): 395.8 (MH+, 100%).

Sources & evidence

ORD record
ord-c88ee0b9e7394a2686403778056b6f1a
Source dataset
uspto-grants-2004_02
Patent number
US06686381B2

Reaction notes

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