Triethylamine → HCID 20616897, compound

Participants

Reaction Steps

A mixture of 11.9 mg (0.04 mmol) [2-(3-Amino-propylamino)-thiazol-5-yl]-phenyl-methanone hydrochloride, 5.8 mg (0.048 mmol) pentanoyl chloride and 39 ul (0.28 mmol) NEt3 in 1 ml methanol and 0.5 ml DCM was stirred at room temperature for 16 h. After evaporation to dryness the residue was taken up in 1.5 ml MeOH/formic acid 1/1 and subjected to preparative HPLC separation on reversed phase eluting with an acetonitrile/water gradient. Evaporation of product fractions yielded 6 mg (43%) of the title compound.

Provenance & Evidence