反应详情

A mixture of 7 g (47.23 mmol) 1-o-Tolyl-propan-2-one, 30.5 g (0.141 mol) pyridinium chlorochromate and 11.2 g (0.141 mol) pyridine in 200 ml DCM was heated to reflux for 16 h. The mixture was filtered through a pad of silica and the filtrate was evaporated under reduced pressure. The residue was purified by flash column chromatography on silica eluting with ethyl acetate/n-hexane 1:4. The product fractions were evaporated to yield 1.178 g (15%) of the title compound.

1. temperaturewas heated
2. temperatureto reflux for 16 h
3. filtrationThe mixture was filtered through a pad of silica
4. customthe filtrate was evaporated under reduced pressure
5. customThe residue was purified by flash column chromatography on silica eluting with ethyl acetate/n-hexane 1:4
6. customThe product fractions were evaporated