Formic Acid → HCID 20616889, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 15.6 mg (0.5 mmol) [2-(3-Amino-propylamino)-thiazol-4-yl]-o-tolyl-methanone hydrochloride in 1 ml methanol was treated with 11.9 mg (0.65 mmol) thiophene-2-sulfonyl chloride in 0.13 ml dioxane and 34.7 ul NEt3. The mixture was stirred at 60° C. for 16 h and after addition of 0.5 ml formic acid subjected to preparative HPLC separation on reversed phase eluting with an acetonitrile/water gradient. Evaporation of the product fractions yielded 6.2 mg (29%) of the title compound.

Provenance & Evidence