2-Bromo-2'-methylacetophenone → HCID 20616898, compound

HRID 2119603Notes

Reaction equation

HRID 2119603 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][CH2:8][CH2:9][NH:10][C:11]([N:13]=[CH:14]N(C)C)=[S:12])([CH3:4])([CH3:3])[CH3:2].[CH3:19][C:20]1[CH:29]=[CH:28][CH:27]=[CH:26][C:21]=1[C:22](=[O:25])[CH2:23]Br>>[C:1]([O:5][C:6](=[O:18])[NH:7][CH2:8][CH2:9][NH:10][C:11]1[S:12][C:23]([C:22](=[O:25])[C:21]2[CH:26]=[CH:27][CH:28]=[CH:29][C:20]=2[CH3:19])=[CH:14][N:13]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 124306762-Bromo-2'-methylacetophenoneHCID 72522556HCID 72522556, compound

Product 1

HCID 20616898HCID 20616898, compoundYield 75%

Procedure

The title compound was synthesised from [2-(3-Dimethylaminomethylene-thioureido)-ethyl]-carbamic acid tert-butyl ester and 2-methyl phenacylbromide (Literature: WO9907666) according to the procedure described for Example 25 in 75% yield. MS (m/e): 362.1 (MH+, 100%).

Sources & evidence

ORD record
ord-efab3f09035347338a3830fc93a1cefb
Source dataset
uspto-grants-2004_02
Patent number
US06686381B2

Reaction notes

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