Potassium Hydroxide → HCID 23442314, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-[(1-methyl-9-oxo-4,9-dihydro-1H-pyrazolo[4,3-b]quinolin-7-yl)methyl]benzonitrile (EXAMPLE 28, step 2, 100 mg, 0.32 mmol) and powdered potassium hydroxide (89 mg, 1.59 mmol) in 2-methyl-2-propanol (5 ml) and dimethylsulfoxide (2 ml) was stirred at 65° C. for 4.5 h. After cooling to room temperature, the mixture was poured into saturated aqueous ammonium chloride (50 ml), and the precipitate was collected by filtration. This yellow powder was washed with water, methanol and dichloromethane to give 55 mg (52%) of the title compound as a yellow solid.

Provenance & Evidence