HCID 23442386, compound → HCID 23442423, compound

Participants

Reaction Steps

A solution of 7-benzoyl-1-methyl-1,4-dihydro-9H-pyrazolo[4,3-b]quinolin-9-one (EXAMPLE 36, step 1, 33 mg, 0.11 mmol) in phosphorus oxychloride (3 ml) was refluxed for 3 h. After evaporation, the residue was dissolved in ethyl acetate (20 ml) and washed with saturated aqueous sodium bicarbonate (20 ml). The water layer was extracted with ethyl acetate (20 ml×2) and the combined organic layer was dried over sodium sulfate. Removal of solvent gave an oily residue, which was purified by preparative thin layer chromatography developing with ethyl acetate/hexane (2:1) to afford 24 mg (69%) of the title compound as a white solid.

Provenance & Evidence