Ethanol → HCID 23442320, compound

Participants

Reaction Steps

A mixture of 9-chloro-1-methyl-8-(4-nitrophenyl)-1H-pyrazolo[4,3-b]quinoline (EXAMPLE 41, step 1, 45 mg, 0.13 mmol), iron powder (37 mg, 0.67 mmol) and ammonium chloride (0.7 mg, 0.013 mmol) in a mixture of ethanol (4 ml) and water (1.5 ml) was refluxed for 8 h. After cooling to room temperature, the mixture was filtered through a pad of Celite. The filtrate was concentrated, dissolved in ethyl acetate (300 ml), washed with water (100 ml) and dried over magnesium sulfate. Removal of solvent gave 41 mg (99%) of the title compound as a solid.

Provenance & Evidence