Phosphorus oxychloride → HCID 9835647, compound

Participants

Reaction Steps

A mixture of 1-methyl-7-nitro-1,4-dihydro-9H-pyrazolo[4,3-b]-quinolin-9-one ((Stepanov et. al., Chem. Heterocycl. Compd. (Engl. Transl.), 1985, 21, 905), 0.13 g, 0.53 mmol) and phosphorus oxychloride (3 ml) was refluxed for 3 h. After evaporation, the obtained residue was dissolved in ethyl acetate (100 ml), washed with saturated sodium bicarbonate (50 ml) and dried over sodium sulfate. Removal of solvent gave a residue which was chromatographed on a column of silica gel eluting with ethyl acetate/dichloromethane/hexane (1:4:4) to give 104 mg (78%) of the title compound as a solid.

Provenance & Evidence