Water → HCID 23442367, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(2-chloroethyl)-1,7-dimethyl-1,4-dihydro-9H-pyrazolo[4,3-b]quinolin-9-one (EXAMPLE 62, step 3, 109 mg, 0.396 mmol) in N,N-dimethylformamide (7 ml) was added sodium azide (77 mg, 1.2 mmol) at room temperature. The resulting mixture was heated at 70° C. for 9.5 h. After cooling to room temperature, water (50 ml) was added and extracted with ethyl acetate (50 ml×3). The combined organic layer was dried over magnesium sulfate and concentrated in vacuo to give 110 mg (99%) of the title compound as a yellow solid.

Provenance & Evidence