Acetone → 3-(4-Fluorophenyl)-4-(2-fluoro-4-methylsulfonylphenyl)-2,5-dihydro-2-furanone

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(4-fluorophenyl)-4-(2-fluoro-4-methylsulfanylphenyl)-2,5-dihydro-2-furanone (6 g, 18.8 mmol) (obtained in step 2) in acetone (150 ml) was added a solution of oxone (34.8 g, 56.6 mmol) in water (75 ml). The reaction mixture was stirred vigorously for 2 h at 25° C. After completion of the reaction solvent was removed under low vacuum and water (200 ml) was added to it. The mixture was then extracted with EtOAc (2×100 ml), organic layers collected, combined, dried over anhydrous Na2SO4 and concentrated under vacuum. The crude product was then treated with MeOH (2×20 ml) and filtered to give 5.6 g of title compound in 85% yield as off white powder. m.p. 160°-162° C.

Provenance & Evidence