化工社化工社 化学情報印刷レポート · 研究参考用
Iodine → 7-Iodo-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Nitric acid, 1,1-dimethylethyl ester | HCID 164756 | — |
| 反応物 | HCID 68490965 | HCID 68490965 | — |
| 触媒 | Copper iodide | HCID 83717 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 7-Iodo-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone | HCID 68489103 | 62% |
反応手順
In a similar manner to Step 4 of Example 140, 7-amino-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone (43.0 mg, 0.110 mmol) was dissolved in acetonitrile (6 mL), and the solution was treated with potassium iodide (29.2 mg, 0.176 mmol), copper iodide (33.5 mg, 0.896 mmol), iodine (44.7 mg, 0.896 mmol) and tert-butyl nitrate (0.059 mL, 0.50 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=5/1) to obtain 7-iodo-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone (33.8 mg, yield 62%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-100dff266892419abdae4dd1417ca2ae |
| 出典メモ | uspto-grants-2010_06 |