Methyl chloroformate → HCID 9841529, compound

HRID 2119747Notes

Reaction equation

HRID 2119747 reaction equation
[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][NH2:21])=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:7].Cl[C:24]([O:26][CH3:27])=[O:25]>>[CH3:1][CH:2]([CH3:22])[CH2:3][CH2:4][NH:5][C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH2:20][NH:21][C:24]([O:26][CH3:27])=[O:25])=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:7]

Participants

3

Reactant 2

HCID 6586Methyl chloroformateHCID 673161092'-Aminomethylbiphenyl-2-carboxylic acid (3-methylbutyl)amide

Product 1

HCID 9841529HCID 9841529, compound

Procedure

From 0.34 mmol of 2′-aminomethylbiphenyl-2-carboxylic acid (3-methyl-butyl)amide (precursor 5c) and methyl chloroformate, according to the general working procedure followed by extraction with EA and purification by flash chromatography 29 mg of 2′-(methoxycarbonylaminomethyl)-biphenyl-2-carboxylic acid (3-methylbutyl)amide were obtained as a resin. MS (ES+): m/e=355 (M+1).

Workup

  1. extractionfollowed by extraction with EA and purification by flash chromatography 29 mg of 2′-(methoxycarbonylaminomethyl)-biphenyl-2-carboxylic acid (3-methylbutyl)amide
  2. customwere obtained as a resin

Sources & evidence

ORD record
ord-890c27e088f34bfc85c71355e45b3581
Source dataset
uspto-grants-2004_02
Patent number
US06686395B2

Reaction notes

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