Benzoyl chloride → HCID 178521697, compound

HRID 2119776Notes

Reaction equation

[C@@H:1]1([N:10]2[C:18]([NH2:19])=[C:17]3[C:13](=[N:14][CH:15]=[N:16]3)[N:12]=[CH:11]2)[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3].[C:20](Cl)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C@@H:1]1([N:10]2[C:18]([NH:19][C:20](=[O:27])[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[C:17]3[C:13](=[N:14][CH:15]=[N:16]3)[N:12]=[CH:11]2)[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3]

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 178507176HCID 178507176, compound

Product 1

HCID 178521697HCID 178521697, compound

Procedure

introducing an acyl group at the N6 position of 1-β-D-arabinofuranosyl adenine with an acylating agent, for example, using benzoyl chloride under conditions suitable for obtaining 1-β-D-arabinofuranosyl-N6-benzoyl adenine,

Sources & evidence

ORD record: ord-0eec80f1452548d88c050a8c7d64060b
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06686463B2

Reaction notes

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