Benzoyl chloride → HCID 131724329, compound

HRID 2119778Notes

Reaction equation

[C:1]([CH:5]([OH:35])[C@H:6]1[O:10][C@@H:9]([N:11]2[C:20]3[C:14]([C:15]([N:17]=[CH:18][N:19]=3)=[NH:16])=[N:13][C:12]2=[SiH2:21])[C@H:8]([O:22][Si:23]([C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:25])[CH3:24])[C@@H:7]1[O:30][C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:4])([CH3:3])[CH3:2].[C:36](Cl)(=[O:43])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[C:1]([CH:5]([OH:35])[C@H:6]1[O:10][C@@H:9]([N:11]2[C:20]3[C:14]([C:15]([N:17]=[CH:18][N:19]=3)=[N:16][C:36](=[O:43])[C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)=[N:13][C:12]2=[SiH2:21])[C@H:8]([O:22][Si:23]([C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:25])[CH3:24])[C@@H:7]1[O:30][C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 7412Benzoyl chloride

HCID 131724330HCID 131724330, compound

Product 1

HCID 131724329HCID 131724329, compound

Procedure

introducing an acyl group at the N6 position of the product from step (2) with an acylating agent, for example, using benzoyl chloride under conditions suitable for obtaining 5′,3′-O-di-tert-butylsilanediyl-2′-O-tert-butyldimethylsilyl-N6-benzoyl adenosine,

Sources & evidence

ORD record: ord-ce7575965a614adf85735398072f9161
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06686463B2

Reaction notes

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