Potassium Hydroxide → Paroxetine

Participants

Reaction Conditions

Reaction Steps

A common procedure is disclosed in EP223403, and corresponding U.S. Pat. No. 4,721,723, wherein a solid-state paroxetine phenylcarbamate (3) was dissolved in toluene and KOH was added. The mixture was refluxed for 2 hours with good agitation. The slurry was then cooled to 20° C. and the toluene washed with water. The obtained solution of paroxetine free base in toluene was further treated with HCI to isolate paroxetine in a form of its hydrochloride salt. Similar procedures for the synthesis of paroxetine and various salts of paroxetine have been disclosed in WO 99-32484, GB 2336364, WO 99-52901, WO 00-39090 and WO 00-32594.

Provenance & Evidence