Ethyl Acetate → Paroxetine

Participants

Reaction Steps

In the production of paroxetine mesylate, ethyl acetate or ethanol are the most suitable solvents for the salt formation. In an industrially suitable process, paroxetine obtained by the present process is dissolved in said solvent at increased temperature, preferably between 50° C. and 70° C. and methane sulphonic acid is added at the same temperature to the solution. The resulting solution is cooled to a temperature close to ambient, e.g. 20° C.-30° C., inoculated with a seeding crystal and cooled to about 0° C. After stirring at the same temperature for 0.5-3 hours, the solid product is filtered or centrifuged and washed with the same solvent. If necessary, the product may be recrystallized, advantageously from the same solvent.

Provenance & Evidence