5-Chloro-2-methylphenyl isothiocyanate → HCID 9947534, compound

HRID 2119799Notes

Reaction equation

HRID 2119799 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([N:8]=[C:9]=[S:10])[CH:7]=1.[CH2:12]([O:14][C:15](=[O:23])[CH2:16][C:17]1[N:18]=[C:19]([NH2:22])[S:20][CH:21]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:23])[CH2:16][C:17]1[N:18]=[C:19]([NH:22][C:9]([NH:8][C:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[CH3:11])=[S:10])[S:20][CH:21]=1)[CH3:13]

Participants

3

Reactant 2

HCID 295195-Chloro-2-methylphenyl isothiocyanateHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 9947534HCID 9947534, compoundYield 40%

Procedure

Prepared using Method B from 4.5 g (24.5 mmol) of 5-chloro-2-methyl-phenyl isothiocyanate and 4.56 g (24.5 mmol) of 2-(2-amino-thiazol-4-yl)-acetic acid ethyl ester to give 3.62 g of title compound as a white solid (40% yield, m.p. 177-179° C.).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-a42019495cae4d95b823bdf09cc55e0b
Source dataset
uspto-grants-2004_02
Patent number
US06686476B2

Reaction notes

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