HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 2-Tetralone-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 2-Tetralone-6-carboxamide ethylene ketal | HCID 57099473 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-Tetralone-6-carboxamide | HCID 22147777 | 38.3% |
Reaction Steps
2-Tetralone-6-carboxamide ethylene ketal (250 mg, 1.07 mmol) and catalytic p-toluenesulfonic acid were stirred in acetone (50 mL) at ambient temperature for 48 hours. The volatiles were removed in vacuo and the residue triturated in ethyl acetate. The solids were filtered, washed and dried to yield 77.5 mg (38%) of 2-tetralone-6-carboxamide as a white powder, pure by NMR, TLC. MS.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06686372B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-595cc430dc1f4d29baa5770110fe631a |
| Source note | uspto-grants-2004_02 |