HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2,4-dioxovalerate → Ethyl 5-methylisoxazole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2,4-dioxovalerate | HCID 69208 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 5-methylisoxazole-3-carboxylate | HCID 76677 | — |
Reaction Steps
To a solution of ethyl-2,4-dioxovalerate in ethanol is added hydroxylamine hydrochloride and sodium hydrogen carbonate. The reaction mixture is then heated under reflux for 1 hour. After cooling, the mixture is evaporated to leave a clear liquid that was distilled to leave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06686352B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-b38f7e11630e4136bdbf3c57897e38a1 |
| Source note | uspto-grants-2004_02 |