2-(4-Methoxyphenyl)ethanimidamide hydrochloride → 5,7-Dihydro-2-[(4-methoxyphenyl)methyl]-6h-pyrimido[5,4-d][1]benzazepine-6-one

HRID 2119950Notes

Reaction equation

HRID 2119950 reaction equation
CN([CH:4]=[C:5]1[C:11](=O)[C:10]2[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=2[NH:8][C:7](=[O:17])[CH2:6]1)C.Cl.[CH3:19][O:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH2:30])=[NH:29])=[CH:23][CH:22]=1>>[CH3:19][O:20][C:21]1[CH:22]=[CH:23][C:24]([CH2:27][C:28]2[N:30]=[CH:4][C:5]3[CH2:6][C:7](=[O:17])[NH:8][C:9]4[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=4[C:11]=3[N:29]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 122033942-(4-Methoxyphenyl)ethanimidamide hydrochlorideHCID 669347634-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 234409755,7-Dihydro-2-[(4-methoxyphenyl)methyl]-6h-pyrimido[5,4-d][1]benzazepine-6-oneYield 31%

Procedure

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-3,4-dihydro-1H-benzazepine-2,5-dione and 2-(4-methoxyphenyl)-acetamidine hydrochloride. Yield: 31%. White solid, m/z (ISP) 332 (MH).

Sources & evidence

ORD record
ord-0bedff4cc2a74bcaa7ee6cbb9a038f23
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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