2-(1H-indol-3-yl)ethanimidamide → 5,7-Dihydro-2-(1h-indol-3-ylmethyl)-6h-pyrimido[5,4-d][1]benzazepine-6-one

HRID 2119951Notes

Reaction equation

HRID 2119951 reaction equation
CN([CH:4]=[C:5]1[C:11](=O)[C:10]2[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=2[NH:8][C:7](=[O:17])[CH2:6]1)C.[NH:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:20]([CH2:27][C:28]([NH2:30])=[NH:29])=[CH:19]1>>[NH:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:20]([CH2:27][C:28]2[N:30]=[CH:4][C:5]3[CH2:6][C:7](=[O:17])[NH:8][C:9]4[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=4[C:11]=3[N:29]=2)=[CH:19]1

Participants

3

Reactant 2

HCID 40466392-(1H-indol-3-yl)ethanimidamideHCID 669347634-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 234410035,7-Dihydro-2-(1h-indol-3-ylmethyl)-6h-pyrimido[5,4-d][1]benzazepine-6-oneYield 80%

Procedure

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-3,4-dihydro-1H-benzazepine-2,5-dione and 2-(1H-indol-3-yl)-acetamidine. Yield: 80%.

Sources & evidence

ORD record
ord-a895d5359ac640cc87c8d82874037821
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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