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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2119954Generated: October 30, 2026

2-Methylpropanimidamide hydrochloride → 10-Fluoro-5,7-dihydro-2-(1-methylethyl)-6h-pyrimido[5,4-d][1]benzazepin-6-one

https://huagongshe.com/reaction/2119954

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methylpropanimidamide hydrochlorideHCID 2782053—
Reactant4-Dimethylaminomethylene-7-fluoro-3,4-dihydro-1H-benzo[b]azepine-2,5-dioneHCID 66934610—
Product10-Fluoro-5,7-dihydro-2-(1-methylethyl)-6h-pyrimido[5,4-d][1]benzazepin-6-oneHCID 2344097160%

Reaction Steps

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-7-fluoro-3,4-dihydro-1H-benzazepine-2,5-dione and isobutyramidine hydrochloride. Yield: 60%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06686352B2
Source datasetuspto-grants-2004_02
ORD IDord-b9848bc7ce5e4c0b8fbb296110d47f45
Source noteuspto-grants-2004_02