Propanimidamide, 2,2-dimethyl-, hydrochloride (1:1) → 2-(1,1-Dimethylethyl)-10-fluoro-5,7-dihydro-6h-pyrimido[5.4-d][1]benzazepin-6-one

HRID 2119956Notes

Reaction equation

HRID 2119956 reaction equation
CN([CH:4]=[C:5]1[C:11](=O)[C:10]2[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:9]=2[NH:8][C:7](=[O:18])[CH2:6]1)C.Cl.[CH3:20][C:21]([CH3:26])([CH3:25])[C:22]([NH2:24])=[NH:23]>>[CH3:20][C:21]([C:22]1[N:23]=[CH:4][C:5]2[CH2:6][C:7](=[O:18])[NH:8][C:9]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:10]=3[C:11]=2[N:24]=1)([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 2781880Propanimidamide, 2,2-dimethyl-, hydrochloride (1:1)HCID 669346104-Dimethylaminomethylene-7-fluoro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 234409642-(1,1-Dimethylethyl)-10-fluoro-5,7-dihydro-6h-pyrimido[5.4-d][1]benzazepin-6-oneYield 54%

Procedure

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-7-fluoro-3,4-dihydro-1H-benzazepine-2,5-dione and 2,2-dimethylpropionamidine hydrochloride. Yield: 54%.

Sources & evidence

ORD record
ord-47a3f700bfa0463e9115c80d7fe11840
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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