2-(4-Methoxyphenyl)ethanimidamide hydrochloride → 10-Fluoro-5,7-dihydro-2-[(4-methoxyphenyl)methyl]-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119957Notes

Reaction equation

HRID 2119957 reaction equation
CN([CH:4]=[C:5]1[C:11](=O)[C:10]2[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:9]=2[NH:8][C:7](=[O:18])[CH2:6]1)C.Cl.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29]([NH2:31])=[NH:30])=[CH:24][CH:23]=1>>[F:17][C:14]1[CH:15]=[CH:16][C:9]2[NH:8][C:7](=[O:18])[CH2:6][C:5]3[CH:4]=[N:30][C:29]([CH2:28][C:25]4[CH:24]=[CH:23][C:22]([O:21][CH3:20])=[CH:27][CH:26]=4)=[N:31][C:11]=3[C:10]=2[CH:13]=1

Participants

3

Reactant 2

HCID 122033942-(4-Methoxyphenyl)ethanimidamide hydrochlorideHCID 669346104-Dimethylaminomethylene-7-fluoro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 2344095210-Fluoro-5,7-dihydro-2-[(4-methoxyphenyl)methyl]-6h-pyrimido[5,4-d][1]benzazepin-6-one

Procedure

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-7-fluoro-3,4-dihydro-1H-benzazepine-2,5-dione and 2-(4-methoxyphenyl)-acetamidine hydrochloride.

Sources & evidence

ORD record
ord-10467cec99e94da995c6b3f7cd574612
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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