Cyclopropanecarboximidamide hydrochloride → 10-Chloro-2-cyclopropyl-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119961Notes

Reaction equation

HRID 2119961 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8](=[CH:13]N(C)C)[C:7](=O)[C:6]=2[CH:18]=1.Cl.[CH:20]1([C:23]([NH2:25])=[NH:24])[CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8]3[CH:13]=[N:24][C:23]([CH:20]4[CH2:22][CH2:21]4)=[N:25][C:7]=3[C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 2781916Cyclopropanecarboximidamide hydrochlorideHCID 669347277-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 2344096210-Chloro-2-cyclopropyl-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-oneYield 83%

Procedure

Analogous to Scheme 1, from 7-chloro-4-[(dimethylamino)methylene]-3,4-dihydro-1H-benzazepine-2,5-dione and cyclopropancarboxamidine hydrochloride. Yield: 83%.

Sources & evidence

ORD record
ord-a9a89df0572c49fd94de7422d83e6416
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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