HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propanimidamide, 2,2-dimethyl-, hydrochloride (1:1) → 10-Chloro-2-(1,1-dimethylethyl)-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propanimidamide, 2,2-dimethyl-, hydrochloride (1:1) | HCID 2781880 | — |
| Reactant | 7-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 66934727 | — |
| Product | 10-Chloro-2-(1,1-dimethylethyl)-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-one | HCID 23440928 | 88% |
Reaction Steps
Analogous to Scheme 1, from 7-chloro-4-[(dimethylamino)methylene]-3,4-dihydro-1H-benzazepine-2,5-dione and 2,2-dimethylpropionamidine hydrochloride. Yield: 88%. Off-white solid, m/z (ISP) 302 (MH)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06686352B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-9bab0709aa354225ba8bd966e388db17 |
| Source note | uspto-grants-2004_02 |