HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Methoxyphenyl)ethanimidamide hydrochloride → 10-Chloro-5,7-dihydro-2-[(4-methoxyphenyl)methyl]-6h-pyrimido[5,4-d][1]benzazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Methoxyphenyl)ethanimidamide hydrochloride | HCID 12203394 | — |
| Reactant | 7-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 66934727 | — |
| Product | 10-Chloro-5,7-dihydro-2-[(4-methoxyphenyl)methyl]-6h-pyrimido[5,4-d][1]benzazepin-6-one | HCID 23440955 | 87% |
Reaction Steps
Analogous to Scheme 1, from 7-chloro-4-[(dimethylamino)methylene]-3,4-dihydro-1H-benzazepine-2,5-dione and 2-(4-methoxyphenyl)-acetamidine hydrochloride. Yield: 87%. White solid, m/z (ISP) 366 (MH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06686352B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-6d0ed696cb454fa3b6b1c1ab67557ebb |
| Source note | uspto-grants-2004_02 |