2-(1H-indol-3-yl)ethanimidamide → 10-Chloro-5,7-dihydro-2-(1h-indol-3-ylmethyl)-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119964Notes

Reaction equation

HRID 2119964 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8](=[CH:13]N(C)C)[C:7](=O)[C:6]=2[CH:18]=1.[NH:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([CH2:28][C:29]([NH2:31])=[NH:30])=[CH:20]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8]3[CH:13]=[N:30][C:29]([CH2:28][C:21]4[C:22]5[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=5)[NH:19][CH:20]=4)=[N:31][C:7]=3[C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 40466392-(1H-indol-3-yl)ethanimidamideHCID 669347277-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 2344100510-Chloro-5,7-dihydro-2-(1h-indol-3-ylmethyl)-6h-pyrimido[5,4-d][1]benzazepin-6-oneYield 46%

Procedure

Analogous to Scheme 1, from 7-chloro-4-[(dimethylamino)methylene]-3,4-dihydro-1H-benzazepine-2,5-dione and 2-(1H-indol-3-yl)-acetamidine. Yield: 46%.

Sources & evidence

ORD record
ord-a124dbcf466740ee836d18a86951f552
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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