Formamidine acetate → 10-Bromo-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119966Notes

Reaction equation

HRID 2119966 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8](=[CH:13][N:14](C)[CH3:15])[C:7](=O)[C:6]=2[CH:18]=1.C(O)(=O)C.C(N)=[NH:24]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8]3[CH:13]=[N:14][CH:15]=[N:24][C:7]=3[C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 160693Formamidine acetateHCID 66934668HCID 66934668, compound

Product 1

HCID 2344096710-Bromo-5,7-dihydro-6h-pyrimido[5,4-d][1]benzazepin-6-oneYield 83%

Procedure

Analogous to Scheme 1, from 7-bromo-4-[(dimethylamino)methylene]-3,4-dihydro-1H-benzazepine-2,5-dione and formamidine acetate. Yield: 83%.

Sources & evidence

ORD record
ord-11e8b725b62340ffbf5b055577b48eb0
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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