Hydrochloric Acid → HCID 69922862, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-methyl-9H-imidazo[1,5-a]pyrimido[5,4-d][1]benzazepine-10-carboxylic acid ethyl ester (1.6 g, 5 mmol) in EtOH (20 mL) was added sodium hydroxide (0.22 g, 5.5 mmol) and water (3.5 mL) and the resulting mixture was heated under reflux for 20 min. The mixture was then cooled to 0° C. and then hydrochloric acid (4 N, 1.32 mL) was added and the mixture was cooled in an ice-bath for 1 h. A solid formed and was filtered off and then dried under vacuum to leave the product (1.1 g, 77%) as off-white crystals, mp 285-287° C., m/z 292 (M).

Provenance & Evidence