Butanimidamide hydrochloride → 5,7-Dihydro-9,10-dimethyl-2-propyl-6h-pyrimido[5,4-d]benzazepine-6-one

HRID 2119976Notes

Reaction equation

HRID 2119976 reaction equation
CN([CH:4]=[C:5]1[C:11](=O)[C:10]2[CH:13]=[C:14]([CH3:18])[C:15]([CH3:17])=[CH:16][C:9]=2[NH:8][C:7](=[O:19])[CH2:6]1)C.Cl.[C:21]([NH2:26])(=[NH:25])[CH2:22][CH2:23][CH3:24]>>[CH3:17][C:15]1[C:14]([CH3:18])=[CH:13][C:10]2[C:11]3[N:26]=[C:21]([CH2:22][CH2:23][CH3:24])[N:25]=[CH:4][C:5]=3[CH2:6][C:7](=[O:19])[NH:8][C:9]=2[CH:16]=1

Participants

3

Reactant 2

HCID 12828983Butanimidamide hydrochlorideHCID 699235554-[(Dimethylamino)methylene]-3,4-dihydro-7,8-dimethyl-1h-benzazepine-2,5-dione

Product 1

HCID 234409345,7-Dihydro-9,10-dimethyl-2-propyl-6h-pyrimido[5,4-d]benzazepine-6-oneYield 67%

Procedure

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-3,4-dihydro-7,8-dimethyl-1H-benzazepine-2,5-dione and butyramidine hydrochloride. Yield: 67%.

Sources & evidence

ORD record
ord-6838a1d9d74a4dec9d5226a80974f624
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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