2-(4-Methoxyphenyl)ethanimidamide hydrochloride → 5,7-Dihydro-2-[(4-methoxyphenyl)methyl]-9,10-dimethyl-6h-pyrimido[5,4-d]benzazepine-6-one

HRID 2119977Notes

Reaction equation

HRID 2119977 reaction equation
CN([CH:4]=[C:5]1[C:11](=O)[C:10]2[CH:13]=[C:14]([CH3:18])[C:15]([CH3:17])=[CH:16][C:9]=2[NH:8][C:7](=[O:19])[CH2:6]1)C.Cl.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30]([NH2:32])=[NH:31])=[CH:25][CH:24]=1>>[CH3:21][O:22][C:23]1[CH:24]=[CH:25][C:26]([CH2:29][C:30]2[N:32]=[CH:4][C:5]3[CH2:6][C:7](=[O:19])[NH:8][C:9]4[CH:16]=[C:15]([CH3:17])[C:14]([CH3:18])=[CH:13][C:10]=4[C:11]=3[N:31]=2)=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 122033942-(4-Methoxyphenyl)ethanimidamide hydrochlorideHCID 699235554-[(Dimethylamino)methylene]-3,4-dihydro-7,8-dimethyl-1h-benzazepine-2,5-dione

Product 1

HCID 234409965,7-Dihydro-2-[(4-methoxyphenyl)methyl]-9,10-dimethyl-6h-pyrimido[5,4-d]benzazepine-6-oneYield 79%

Procedure

Analogous to Scheme 1,from 4-[(dimethylamino)methylene]-3,4-dihydro-7,8-dimethyl-1H-benzazepine-2,5-dione and 2-(4-methoxyphenyl)-acetamidine hydrochloride. Yield: 79%.

Sources & evidence

ORD record
ord-e5182ccde6aa4785abbd2801aa418baf
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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